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Clinical and Pulmonary Function Markers of Respiratory Exacerbation Risk in Subjects With Quadriplegic Cerebral Palsy.
- Source :
-
Respiratory care [Respir Care] 2015 Oct; Vol. 60 (10), pp. 1431-7. Date of Electronic Publication: 2015 Apr 28. - Publication Year :
- 2015
-
Abstract
- Background: Although respiratory exacerbations are common in patients with quadriplegic cerebral palsy (CP), little is known about the factors that are related to increased exacerbation risk. This study aimed to identify the clinical and pulmonary function variables signaling risk of exacerbation in this type of patient.<br />Methods: Thirty-one children and young adults with quadriplegic CP underwent a comprehensive history, physical examination, and pulmonary function test, including arterial blood gas analysis, airway resistance using the interrupter technique, and home overnight SpO2 monitoring. Subjects were divided into 2 groups depending on the number of respiratory exacerbations reported during the year before study entry: frequent exacerbators (ie, ≥ 2 exacerbations) and infrequent exacerbators (ie, < 2 exacerbations).<br />Results: The frequent exacerbators were more likely to require hospitalization due to respiratory disorders compared with the infrequent exacerbators (13/14 vs 9/17, P = .02). Respiratory exacerbation was found to be associated with diagnosis of gastroesophageal reflux (adjusted odds ratio of 23.95 for subjects with confirmed diagnosis, P = .02) and higher PaCO2 levels (adjusted odds ratio of 12.60 for every 5-mm Hg increase in PaCO2 , P = .05). Subjects with PaCO2 ≥ 35 mm Hg showed an exacerbation odds ratio of 15.2 (95% CI 1.5-152.5, P = .01).<br />Conclusions: Gastroesophageal reflux and increased PaCO2 can be considered simple, clinically useful markers of increased exacerbation risk in young subjects with quadriplegic CP.<br /> (Copyright © 2015 by Daedalus Enterprises.)
- Subjects :
- Adolescent
Anthropometry
Blood Gas Analysis
Cerebral Palsy complications
Child
Disease Progression
Female
Gastroesophageal Reflux complications
Humans
Male
Odds Ratio
Risk Factors
Biomarkers analysis
Cerebral Palsy physiopathology
Respiratory Function Tests methods
Respiratory Insufficiency etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1943-3654
- Volume :
- 60
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Respiratory care
- Publication Type :
- Academic Journal
- Accession number :
- 25922546
- Full Text :
- https://doi.org/10.4187/respcare.04024