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Human intrabony defect regeneration with rhFGF-2 and hyaluronic acid - a randomized controlled clinical trial.
- Source :
-
Journal of clinical periodontology [J Clin Periodontol] 2015 Jul; Vol. 42 (7), pp. 658-65. Date of Electronic Publication: 2015 Jul 14. - Publication Year :
- 2015
-
Abstract
- Aim: The goal of this study was to evaluate if a biological hydrogel of recombinant human Fibroblast Growth Factor type 2 (rhFGF-2) in a hyaluronic acid (HA) carrier applied in periodontal intrabony defects would enhance the clinical parameters of regeneration of the periodontal attachment apparatus<br />Materials and Methods: Thirty adult patients were evaluated. Two intrabony defects present in contra-lateral quadrants in each patient were randomly allocated for each of the treatment methods employed. Control group (n = 30) were treated by open debridement with the papilla preservation flaps, while the test group (n = 30) also received a topical application of rhFGF-2/HA in the intrabony defect. The parameters evaluated, at baseline and after one year, were, were probing depth (PD), gingival recession (REC), probing attachment level (PAL) and probing bone level (PBL). The primary outcome measures was PAL gain<br />Results: Test sites exhibited significantly more PD reduction (5.5 versus 2.9 mm), PAL gains (4.8 versus 2.2 mm) and shallower residual PD (4.2 versus 6.6 mm) than controls. Moreover, residual PD smaller than 5 mm (100 versus 0%) and PAL gain > 4 mm (60 versus 20%) was significantly more frequent in the test group<br />Conclusion: Application of rhFGF-2/HA significantly improved clinical parameters of periodontal wound healing one year after treatment.<br /> (© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Subjects :
- Adult
Aged
Alveolar Process drug effects
Chronic Periodontitis drug therapy
Debridement methods
Drug Carriers
Female
Follow-Up Studies
Gingival Recession drug therapy
Humans
Male
Middle Aged
Periodontal Attachment Loss drug therapy
Periodontal Pocket drug therapy
Prospective Studies
Radiography, Dental, Digital methods
Recombinant Proteins
Surgical Flaps surgery
Treatment Outcome
Alveolar Bone Loss drug therapy
Bone Regeneration drug effects
Fibroblast Growth Factor 2 therapeutic use
Hyaluronic Acid chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1600-051X
- Volume :
- 42
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of clinical periodontology
- Publication Type :
- Academic Journal
- Accession number :
- 25933201
- Full Text :
- https://doi.org/10.1111/jcpe.12406