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Germline MUTYH gene mutations are not frequently found in unselected patients with papillary breast carcinoma.
- Source :
-
Hereditary cancer in clinical practice [Hered Cancer Clin Pract] 2014 Dec 12; Vol. 12 (1), pp. 21. Date of Electronic Publication: 2014 Dec 12 (Print Publication: 2014). - Publication Year :
- 2014
-
Abstract
- MUTYH-associated polyposis (MAP) is an autosomal recessive disease, which predisposes to polyposis and colorectal cancer. There is a trend towards an increased risk of breast cancer in MAP patients, with a remarkable proportion of papillary breast cancers. To determine whether MUTYH mutations are associated with this specific and rare type of breast cancer, 53 unselected patients with papillary breast cancer were analyzed for founder mutations in the MUTYH gene. No germline mutations were identified, indicating that biallelic MUTYH mutations are not a frequent underlying cause for the development of papillary carcinomas of the breast.
Details
- Language :
- English
- ISSN :
- 1731-2302
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Hereditary cancer in clinical practice
- Publication Type :
- Academic Journal
- Accession number :
- 25937855
- Full Text :
- https://doi.org/10.1186/1897-4287-12-21