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Infections associated with bendamustine containing regimens in hematological patients: a retrospective multi-center study.
- Source :
-
Leukemia & lymphoma [Leuk Lymphoma] 2016; Vol. 57 (1), pp. 63-9. Date of Electronic Publication: 2015 May 25. - Publication Year :
- 2016
-
Abstract
- A multi-center retrospective analysis of a cohort of patients in Israel treated with any bendamustine containing regimen between 2010-2014 was performed in order to determine the incidence and predictors for infection. The Kaplan Meier Model, employing log rank analysis, was used to assess time-to-infection. The Cox Proportional Hazards model was used to analyze multivariate effects of risk and 234 patients were included in the analysis. One hundred and nine (46.6%) developed at least one infection and 33.76% had severe infections. Seventy-six (41.5%) developed bacterial infection, nine (3.8%) fungal infection and 26 (11.5%) had viral infections. Factors significantly associated with time to infection on multivariable analysis were: bendamustine-combinations [hazard ratio (HR) = 0.589 (95% CI = 0.374-0.926), p = 0.022], Hb level [HR = 0.791 (95% CI = 0.716-0.875), p < 0.0001] and ischemic heart disease [HR = 1.828 (95% CI = 1.165-2.868), p = 0.009]. Infections were associated with a higher mortality and hospitalization rate.
- Subjects :
- Aged
Antineoplastic Agents, Alkylating therapeutic use
Bendamustine Hydrochloride therapeutic use
Biomarkers
Female
Hematologic Diseases diagnosis
Hematologic Diseases drug therapy
Hospitalization
Humans
Incidence
Israel epidemiology
Lymphoproliferative Disorders complications
Lymphoproliferative Disorders diagnosis
Lymphoproliferative Disorders drug therapy
Male
Middle Aged
Retrospective Studies
Risk Factors
Antineoplastic Agents, Alkylating adverse effects
Bendamustine Hydrochloride adverse effects
Hematologic Diseases complications
Infections epidemiology
Infections etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1029-2403
- Volume :
- 57
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Leukemia & lymphoma
- Publication Type :
- Academic Journal
- Accession number :
- 25944378
- Full Text :
- https://doi.org/10.3109/10428194.2015.1046862