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An alumina toughened zirconia composite for dental implant application: in vivo animal results.
- Source :
-
BioMed research international [Biomed Res Int] 2015; Vol. 2015, pp. 157360. Date of Electronic Publication: 2015 Apr 06. - Publication Year :
- 2015
-
Abstract
- Ceramic materials are widely used for biomedical applications because of their remarkable biological and mechanical properties. Composites made of alumina and zirconia are particularly interesting owing to their higher toughness with respect to the monolithic materials. On this basis, the present study is focused on the in vivo behavior of alumina toughened zirconia (ATZ) dental implants treated with a hydrothermal process. A minipig model was implemented to assess the bone healing through histology and mRNA expression at different time points (8, 14, 28, and 56 days). The novel ATZ implant was compared to a titanium clinical standard. The implants were analyzed in terms of microstructure and surface roughness before in vivo tests. The most interesting result deals with a statistically significant higher digital histology index for ATZ implants with respect to titanium standard at 56 days, which is an unprecedented finding, to the authors' knowledge. Even if further investigations are needed before proposing the clinical use in humans, the tested material proved to be a promising candidate among the possible ceramic dental implants.
- Subjects :
- Animals
Biomarkers metabolism
Bone Density drug effects
Bone and Bones cytology
Bone and Bones drug effects
Bone and Bones metabolism
Gene Expression Regulation drug effects
Osteogenesis drug effects
Osteogenesis genetics
Surface Properties
Swine
Swine, Miniature
Aluminum Oxide pharmacology
Dental Implants
Materials Testing methods
Zirconium pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 2314-6141
- Volume :
- 2015
- Database :
- MEDLINE
- Journal :
- BioMed research international
- Publication Type :
- Academic Journal
- Accession number :
- 25945324
- Full Text :
- https://doi.org/10.1155/2015/157360