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Does lower limb exercise worsen renal artery hemodynamics in patients with abdominal aortic aneurysm?
- Source :
-
PloS one [PLoS One] 2015 May 06; Vol. 10 (5), pp. e0125121. Date of Electronic Publication: 2015 May 06 (Print Publication: 2015). - Publication Year :
- 2015
-
Abstract
- Renal artery stenosis (RAS) and renal complications emerge in some patients after endovascular aneurysm repair (EVAR) to treat abdominal aorta aneurysm (AAA). The mechanisms for the causes of these problems are not clear. We hypothesized that for EVAR patients, lower limb exercise could negatively influence the physiology of the renal artery and the renal function, by decreasing the blood flow velocity and changing the hemodynamics in the renal arteries. To evaluate this hypothesis, pre- and post-operative models of the abdominal aorta were reconstructed based on CT images. The hemodynamic environment was numerically simulated under rest and lower limb exercise conditions. The results revealed that in the renal arteries, lower limb exercise decreased the wall shear stress (WSS), increased the oscillatory shear index (OSI) and increased the relative residence time (RRT). EVAR further enhanced these effects. Because these parameters are related to artery stenosis and atherosclerosis, this preliminary study concluded that lower limb exercise may increase the potential risk of inducing renal artery stenosis and renal complications for AAA patients. This finding could help elucidate the mechanism of renal artery stenosis and renal complications after EVAR and warn us to reconsider the management and nursing care of AAA patients.
- Subjects :
- Aorta, Abdominal physiopathology
Aortic Aneurysm, Abdominal surgery
Blood Flow Velocity physiology
Endovascular Procedures adverse effects
Humans
Kidney blood supply
Kidney diagnostic imaging
Renal Artery diagnostic imaging
Renal Artery Obstruction physiopathology
Renal Circulation physiology
Stress, Mechanical
Tomography, X-Ray Computed
Aortic Aneurysm, Abdominal physiopathology
Exercise physiology
Hemodynamics physiology
Lower Extremity physiopathology
Renal Artery physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 10
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 25946196
- Full Text :
- https://doi.org/10.1371/journal.pone.0125121