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Genetic variation in the hemagglutinin of A(H1N1) 09pdm and A(H3N2) influenza viruses in the Beijing area from 2009 to 2014.
- Source :
-
Clinical laboratory [Clin Lab] 2015; Vol. 61 (3-4), pp. 289-97. - Publication Year :
- 2015
-
Abstract
- Background: A(H1N1) 09pdm and A(H3N2) influenza viruses are the main cause of occasional influenza pandemics and seasonal influenza epidemics around the world. Unfortunately, the understanding of long-term genetic variation in these viruses remains limited.<br />Methods: In this study, hemagglutinin genes from 90 A(H1N1) 09pdm and 48 A(H3N2) influenza viruses in the Beijing area from 2009 to 2014 were sequenced and analyzed.<br />Results: The hemagglutinin genes in A(H1N1) 09pdm and A(H3N2) shared nucleotide similarity that ranged from 93.06% - 99.88% and 98.68% - 99.29%, respectively, compared with current vaccine strains. 10 and 7 amino acid mutations in antigenic sites were identified in these two strains, respectively. In addition, a new site 177 glycosylation, which did not exist in previous circulating strains, was identified in 3 A(H1N1) 09pdm isolates.<br />Conclusions: This study demonstrated the continued evolution of seasonal influenza viruses in the Beijing area, indicating that an update of the vaccine is needed, especially for A(H1N1) 09pdm influenza virus.
- Subjects :
- China
Computational Biology
Epidemics
Epitopes chemistry
Glycosylation
Humans
Influenza, Human virology
Nucleotides genetics
Open Reading Frames
Phylogeny
RNA, Viral genetics
Genetic Variation
Hemagglutinin Glycoproteins, Influenza Virus genetics
Influenza A Virus, H1N1 Subtype isolation & purification
Influenza A Virus, H3N2 Subtype isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1433-6510
- Volume :
- 61
- Issue :
- 3-4
- Database :
- MEDLINE
- Journal :
- Clinical laboratory
- Publication Type :
- Academic Journal
- Accession number :
- 25974995
- Full Text :
- https://doi.org/10.7754/clin.lab.2014.140816