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Vitamin D and pancreatic cancer: a pooled analysis from the Pancreatic Cancer Case-Control Consortium.
- Source :
-
Annals of oncology : official journal of the European Society for Medical Oncology [Ann Oncol] 2015 Aug; Vol. 26 (8), pp. 1776-83. Date of Electronic Publication: 2015 May 14. - Publication Year :
- 2015
-
Abstract
- Background: The potential role of vitamin D in the aetiology of pancreatic cancer is unclear, with recent studies suggesting both positive and negative associations.<br />Patients and Methods: We used data from nine case-control studies from the International Pancreatic Cancer Case-Control Consortium (PanC4) to examine associations between pancreatic cancer risk and dietary vitamin D intake. Study-specific odds ratios (ORs) were estimated using multivariable logistic regression, and ORs were then pooled using a random-effects model. From a subset of four studies, we also calculated pooled estimates of association for supplementary and total vitamin D intake.<br />Results: Risk of pancreatic cancer increased with dietary intake of vitamin D [per 100 international units (IU)/day: OR = 1.13, 95% confidence interval (CI) 1.07-1.19, P = 7.4 × 10(-6), P-heterogeneity = 0.52; ≥230 versus <110 IU/day: OR = 1.31, 95% CI 1.10-1.55, P = 2.4 × 10(-3), P-heterogeneity = 0.81], with the association possibly stronger in people with low retinol/vitamin A intake.<br />Conclusion: Increased risk of pancreatic cancer was observed with higher levels of dietary vitamin D intake. Additional studies are required to determine whether or not our finding has a causal basis.<br /> (© The Author 2015. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Case-Control Studies
Diabetes Mellitus epidemiology
Diet statistics & numerical data
Dietary Supplements
Female
Humans
Logistic Models
Male
Middle Aged
Multivariate Analysis
Obesity epidemiology
Odds Ratio
Pancreatic Neoplasms epidemiology
Pancreatitis epidemiology
Risk Factors
Adenocarcinoma epidemiology
Pancreatic Neoplasms chemically induced
Vitamin D administration & dosage
Vitamin D adverse effects
Vitamins administration & dosage
Vitamins adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1569-8041
- Volume :
- 26
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Annals of oncology : official journal of the European Society for Medical Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 25977560
- Full Text :
- https://doi.org/10.1093/annonc/mdv236