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miRNA expression atlas in male rat.

Authors :
Minami K
Uehara T
Morikawa Y
Omura K
Kanki M
Horinouchi A
Ono A
Yamada H
Ohno Y
Urushidani T
Source :
Scientific data [Sci Data] 2014 May 27; Vol. 1, pp. 140005. Date of Electronic Publication: 2014 May 27 (Print Publication: 2014).
Publication Year :
2014

Abstract

MicroRNAs (miRNAs) are small (~22 nucleotide) noncoding RNAs that play pivotal roles in regulation of gene expression. The value of miRNAs as circulating biomarkers is now broadly recognized; such tissue-specific biomarkers can be used to monitor tissue injury and several pathophysiological conditions in organs. In addition, miRNA profiles of normal organs and tissues are important for obtaining a better understanding of the source of modulated miRNAs in blood and how those modulations reflect various physiological and toxicological conditions. This work was aimed at creating an miRNA atlas in rats, as part of a collaborative effort with the Toxicogenomics Informatics Project in Japan (TGP2). We analyzed genome-wide miRNA profiles of 55 different organs and tissues obtained from normal male rats using miRNA arrays. The work presented herein represents a comprehensive dataset derived from normal samples profiled in a single study. Here we present the whole dataset with miRNA profiles of multiple organs, as well as precise information on experimental procedures and organ-specific miRNAs identified in this dataset.

Details

Language :
English
ISSN :
2052-4463
Volume :
1
Database :
MEDLINE
Journal :
Scientific data
Publication Type :
Academic Journal
Accession number :
25977763
Full Text :
https://doi.org/10.1038/sdata.2014.5