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A prospective analysis of high-dose-rate endobronchial brachytherapy in the palliation of obstructive symptoms in lung cancer patients: A single-institution experience.
- Source :
-
Brachytherapy [Brachytherapy] 2015 Sep-Oct; Vol. 14 (5), pp. 655-61. Date of Electronic Publication: 2015 May 15. - Publication Year :
- 2015
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Abstract
- Purpose: Obstructive symptoms that affect quality of life (QOL) are commonly caused by endobronchial disease in many patients with locally advanced, inoperable lung cancer. High-dose-rate endobronchial brachytherapy (HDREBBT) has been used to palliate these symptoms, yet its role is not well defined in the literature.<br />Methods and Materials: Ninety-eight patients with locally advanced, inoperable lung cancer received HDREBBT. They were prospectively followed for survival, QOL, and toxicity endpoints. QOL measures were captured using the Quality of Life Questionnaire-Lung Cancer 30 and -Lung Cancer 13.<br />Results: At 1-year follow-up, no significant toxicities were seen. Overall survival was 13.4% at 12 months (mean 192 days). Performance status, additional treatment after HDREBBT and treatment intent affected overall survival on univariate analysis (p < 0.05). Mean hemoptysis-free survival for all patients was 232.3 days, cough-free survival was 140.3 days, and dyspnea-free survival was 173.5 days. There was no impact of any treatment- or patient-related factors of these outcomes on multivariate analysis, including additional treatment modalities and HDREBBT dose.<br />Conclusions: HDREBBT is a safe and effective way to palliate endobronchial symptoms. Additional external-beam radiation therapy, chemotherapy, or chemoradiation after HDREBBT improves survival, but does not affect QOL measures.<br /> (Crown Copyright © 2015. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Aged
Aged, 80 and over
Airway Obstruction etiology
Brachytherapy adverse effects
Carcinoma, Non-Small-Cell Lung complications
Cough etiology
Dyspnea etiology
Female
Hemoptysis etiology
Humans
Lung Neoplasms complications
Male
Middle Aged
Prospective Studies
Radiotherapy Dosage
Survival Rate
Airway Obstruction radiotherapy
Brachytherapy methods
Carcinoma, Non-Small-Cell Lung radiotherapy
Lung Neoplasms radiotherapy
Palliative Care methods
Quality of Life
Subjects
Details
- Language :
- English
- ISSN :
- 1873-1449
- Volume :
- 14
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Brachytherapy
- Publication Type :
- Academic Journal
- Accession number :
- 25983031
- Full Text :
- https://doi.org/10.1016/j.brachy.2015.04.005