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Short- and Long-Term Outcomes of Acute Severe Ulcerative Colitis in Korea: The 1999-2005 Cohort.
- Source :
-
Inflammatory bowel diseases [Inflamm Bowel Dis] 2015 Aug; Vol. 21 (8), pp. 1825-31. - Publication Year :
- 2015
-
Abstract
- Background: No previous studies have evaluated the long-term outcomes of acute severe ulcerative colitis (ASUC) in non-Caucasian populations. The purposes of this study were to evaluate the short- and long-term outcomes of Korean patients with ASUC.<br />Methods: We retrospectively analyzed 99 Korean patients with ASUC who satisfied the criteria given by Truelove and Witts between 1999 and 2005. The short-term outcome parameter was the colectomy rate during index hospitalization, and the long-term outcome parameters were the rates of colectomy and rehospitalization after discharge from index hospitalization.<br />Results: During index hospitalization, 16 of 99 patients (16.2%) underwent colectomy: 6 of 71 responders (8.5%) to intravenous steroids on day 3 versus 10 of 28 nonresponders (35.7%), as assessed using the Oxford index (P = 0.002). Among 83 patients who avoided colectomy during index hospitalization, 13 patients (15.7%) underwent colectomy during the median follow-up period of 10.6 years. The cumulative probability of colectomy tended to be lower in complete responders on day 7 of intravenous steroid therapy (CR7) than in others: 3.7% versus 13.9% at 5 years and 7.6% versus 18.2% at 10 years (P = 0.100). The cumulative probability of rehospitalization was significantly lower in CR7 than in other patients: 20.5% versus 37.5% at 5 years and 31.4% versus 48.2% at 10 years (P = 0.043).<br />Conclusions: Assessing the degree of response to intravenous steroids helps predict the short- and long-term outcomes in patients with ASUC. Korean patients with ASUC may have better clinical courses than Caucasians, as indicated by the lower colectomy rate.
- Subjects :
- Acute Disease
Adolescent
Adult
Aged
Colitis, Ulcerative epidemiology
Female
Follow-Up Studies
Humans
Male
Middle Aged
Prognosis
Remission Induction
Republic of Korea epidemiology
Retrospective Studies
Time Factors
Young Adult
Colectomy statistics & numerical data
Colitis, Ulcerative drug therapy
Colitis, Ulcerative surgery
Hospitalization statistics & numerical data
Immunosuppressive Agents therapeutic use
Severity of Illness Index
Steroids therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1536-4844
- Volume :
- 21
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Inflammatory bowel diseases
- Publication Type :
- Academic Journal
- Accession number :
- 25985248
- Full Text :
- https://doi.org/10.1097/MIB.0000000000000447