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Paratesticular dedifferentiated liposarcoma with prominent myxoid stroma: report of a case and review of the literature.
- Source :
-
Medical molecular morphology [Med Mol Morphol] 2017 Jun; Vol. 50 (2), pp. 112-116. Date of Electronic Publication: 2015 May 19. - Publication Year :
- 2017
-
Abstract
- Paratesticular sarcoma is rare, but liposarcoma is its most common type. Paratesticular liposarcoma sometimes presents as dedifferentiated liposarcoma. Both high-grade and low-grade dedifferentiation have been reported. Herein, we presented a unique case of a 64-year-old man with low-grade dedifferentiated liposarcoma with prominent myxoid stroma. Well-differentiated liposarcoma components extended along the spermatic cord. The constituent cells of the dedifferentiated component were peculiar in that, they were relatively uniform cells with atypia and did not have pleomorphism to such an extent that it mimicked myxofibrosarcoma. This myxoid component was confidently differentiated from myxoid liposarcoma with the help of immunohistochemical analysis using CDK4 and MDM2. These two markers were also expressed in the well-differentiated component. It could therefore be confirmed that this sarcoma is dedifferentiated liposarcoma but is not mixed-type liposarcoma comprising well-differentiated liposarcoma and myxoid liposarcoma.
- Subjects :
- Cyclin-Dependent Kinase 4 genetics
Diagnosis, Differential
Fibrosarcoma diagnostic imaging
Fibrosarcoma genetics
Fibrosarcoma surgery
Gene Expression
Humans
Immunohistochemistry
Liposarcoma, Myxoid diagnostic imaging
Liposarcoma, Myxoid genetics
Liposarcoma, Myxoid surgery
Male
Middle Aged
Neoplasm Grading
Neoplasms diagnostic imaging
Neoplasms genetics
Neoplasms surgery
Proto-Oncogene Proteins c-mdm2 genetics
Scrotum metabolism
Scrotum surgery
Biomarkers, Tumor genetics
Fibrosarcoma pathology
Liposarcoma, Myxoid pathology
Neoplasms pathology
Scrotum pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1860-1499
- Volume :
- 50
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Medical molecular morphology
- Publication Type :
- Academic Journal
- Accession number :
- 25986682
- Full Text :
- https://doi.org/10.1007/s00795-015-0108-1