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The use of saliva as a practical and feasible alternative to urine in large-scale screening for congenital cytomegalovirus infection increases inclusion and detection rates.
- Source :
-
Revista da Sociedade Brasileira de Medicina Tropical [Rev Soc Bras Med Trop] 2015 Mar-Apr; Vol. 48 (2), pp. 206-7. - Publication Year :
- 2015
-
Abstract
- Introduction: Although urine is considered the gold-standard material for the detection of congenital cytomegalovirus (CMV) infection, it can be difficult to obtain in newborns. The aim of this study was to compare the efficiency of detection of congenital CMV infection in saliva and urine samples.<br />Methods: One thousand newborns were included in the study. Congenital cytomegalovirus deoxyribonucleic acid (DNA) was detected by polymerase chain reaction (PCR).<br />Results: Saliva samples were obtained from all the newborns, whereas urine collection was successful in only 333 cases. There was no statistically significant difference between the use of saliva alone or saliva and urine collected simultaneously for the detection of CMV infection.<br />Conclusions: Saliva samples can be used in large-scale neonatal screening for CMV infection.
- Subjects :
- Cytomegalovirus genetics
DNA, Viral analysis
Humans
Infant, Newborn
Polymerase Chain Reaction
Reproducibility of Results
Sensitivity and Specificity
Cytomegalovirus isolation & purification
Cytomegalovirus Infections congenital
Cytomegalovirus Infections diagnosis
Neonatal Screening methods
Saliva virology
Urine virology
Subjects
Details
- Language :
- English
- ISSN :
- 1678-9849
- Volume :
- 48
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Revista da Sociedade Brasileira de Medicina Tropical
- Publication Type :
- Academic Journal
- Accession number :
- 25992937
- Full Text :
- https://doi.org/10.1590/0037-8682-0200-2014