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Prognostic value of PAX3/7-FOXO1 fusion status in alveolar rhabdomyosarcoma: Systematic review and meta-analysis.

Authors :
Kubo T
Shimose S
Fujimori J
Furuta T
Ochi M
Source :
Critical reviews in oncology/hematology [Crit Rev Oncol Hematol] 2015 Oct; Vol. 96 (1), pp. 46-53. Date of Electronic Publication: 2015 May 14.
Publication Year :
2015

Abstract

Purpose: The objective of this systematic review is to provide an unprecedented summary of the prognostic impact of PAX3/7-FOXO1 fusion status in alveolar rhabdomyosarcoma.<br />Methods: Studies evaluating PAX3/7-FOXO1 fusion gene or its variants as a prognostic marker were systematically searched and comparative meta-analysis of overall survival was carried out.<br />Results: A total of 7 studies comprising 993 patients with rhabdomyosarcoma were included. Three eligible studies showed no significant difference of survival between fusion positive and negative alveolar rhabdomyosarcoma. Four eligible studies showed that PAX3-FOXO1 fusion variant may indicate a lower survival probability than PAX7-FOXO1, although the effect did not reach a level of statistical significance (pooled hazard ratios, 1.66; 95% CI, 0.95-2.89; p=0.07).<br />Conclusions: There was no significant difference in the overall survival between patients with the positive and negative fusion gene, but there were indications of PAX3-FOXO1 being an unfavorable prognostic factor.<br /> (Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1879-0461
Volume :
96
Issue :
1
Database :
MEDLINE
Journal :
Critical reviews in oncology/hematology
Publication Type :
Academic Journal
Accession number :
26008753
Full Text :
https://doi.org/10.1016/j.critrevonc.2015.04.012