Back to Search
Start Over
Synthesis of Paclitaxel. 1. Synthesis of the ABC Ring of Paclitaxel by SmI2-Mediated Cyclization.
- Source :
-
Organic letters [Org Lett] 2015 Jun 05; Vol. 17 (11), pp. 2570-3. Date of Electronic Publication: 2015 May 26. - Publication Year :
- 2015
-
Abstract
- A convergent synthesis of the ABC ring of antitumor natural product paclitaxel (Taxol) is described. SmI2-mediated reductive cyclization of an allylic benzoate possessing an aldehyde function, synthesized from tri-O-acetyl-d-glucal and 1,3-cyclohexanedione, smoothly afforded the highly strained 6-8-6 tricarbocyclic structure in 66% yield.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 17
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 26010812
- Full Text :
- https://doi.org/10.1021/acs.orglett.5b01173