First Report of OXA-181-Producing Escherichia coli in China and Characterization of the Isolate Using Whole-Genome Sequencing.

Authors :: Liu Y
Feng Y
Wu W
Xie Y
Wang X
Zhang X
Chen X
Zong Z
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2015 Aug; Vol. 59 (8), pp. 5022-5. Date of Electronic Publication: 2015 May 26.
Publication Year :: 2015
Abstract: We report the first OXA-181-producing strain in China. blaOXA-181 was found in sequence type 410 (ST410) Escherichia coli strain WCHEC14828 from a Chinese patient without recent travel history. Genome sequencing and conjugation experiments were performed. blaOXA-181 was carried on a 51-kb self-transmissible IncX3 plasmid and was linked with qnrS1, a quinolone resistance gene. blaOXA-181 was introduced onto the IncX3 plasmid from a ColE2-type plasmid, and IncX3 plasmids have the potential to mediate the dissemination of blaOXA-181.<br /> (Copyright © 2015, American Society for Microbiology. All Rights Reserved.)

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