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The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses.
- Source :
-
Molecular cancer [Mol Cancer] 2015 Apr 17; Vol. 14, pp. 87. Date of Electronic Publication: 2015 Apr 17. - Publication Year :
- 2015
-
Abstract
- Infection with Human papillomaviruses (HPVs) leads to the development of a wide-range of cancers, accounting for 5% of all human cancers. A prominent example is cervical cancer, one of the leading causes of cancer death in women worldwide. It has been well established that tumor development and progression induced by HPV infection is driven by the sustained expression of two oncogenes E6 and E7. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways that may be equally important for transformation. Among these pathways, the phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signalling cascade plays a very important role in HPV-induced carcinogenesis by acting through multiple cellular and molecular events. In this review, we summarize the frequent amplification of PI3K/Akt/mTOR signals in HPV-induced cancers and discuss how HPV oncogenes E6/E7/E5 activate the PI3K/Akt/mTOR signalling pathway to modulate tumor initiation and progression and affect patient outcome. Improvement of our understanding of the mechanism by which the PI3K/Akt/mTOR signalling pathway contributes to the immortalization and carcinogenesis of HPV-transduced cells will assist in devising novel strategies for preventing and treating HPV-induced cancers.
- Subjects :
- Animals
Ataxia Telangiectasia Mutated Proteins metabolism
Cell Transformation, Viral
Humans
Intracellular Signaling Peptides and Proteins metabolism
Life Cycle Stages
Papillomavirus Infections virology
Protein Serine-Threonine Kinases metabolism
p38 Mitogen-Activated Protein Kinases metabolism
Neoplasms etiology
Neoplasms metabolism
Papillomaviridae physiology
Papillomavirus Infections complications
Phosphatidylinositol 3-Kinases metabolism
Proto-Oncogene Proteins c-akt metabolism
Signal Transduction
TOR Serine-Threonine Kinases metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1476-4598
- Volume :
- 14
- Database :
- MEDLINE
- Journal :
- Molecular cancer
- Publication Type :
- Academic Journal
- Accession number :
- 26022660
- Full Text :
- https://doi.org/10.1186/s12943-015-0361-x