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Differential genomic damage in different tumor lines induced by prodigiosin.
- Source :
-
Anticancer research [Anticancer Res] 2015 Jun; Vol. 35 (6), pp. 3325-32. - Publication Year :
- 2015
-
Abstract
- Prodigiosin is a secondary metabolite produced by Serratia marcercens. As this pigment is suggested to be a cancer drug, genotoxicity studies are necessary. The aim of the present investigation was to evaluate the genotoxic effects of prodigiosin on tumoral and normal cell lines, NCIH-292, MCF-7 and HL-60. A normal line BGMK was used as control. Genomic damage induced by prodigiosin was observed in all tumor lines as well as the control line. The pigment induced the formation of micronuclei in tumor cells. The present data confirm the antitumor potential of prodigiosin. However, these findings also raise concerns regarding its target-specific action, as genotoxic effects on normal cells also occurred.<br /> (Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.)
- Subjects :
- Humans
MCF-7 Cells
Neoplasms pathology
Prodigiosin adverse effects
Serratia chemistry
Serratia pathogenicity
Serratia Infections complications
Serratia Infections drug therapy
Serratia Infections genetics
DNA Damage drug effects
Genome, Human drug effects
Neoplasms drug therapy
Prodigiosin administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7530
- Volume :
- 35
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 26026092