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[Optimization of treatment in hypertensive patients in real clinical practice: Role of a fixed-dose perindopril A and amlodipine combination (Results of the Russian observational CONSTANTA trial].
- Source :
-
Terapevticheskii arkhiv [Ter Arkh] 2015; Vol. 87 (3), pp. 66-70. - Publication Year :
- 2015
-
Abstract
- Aim: To provide a detailed analysis of the efficacy and tolerability of Prestance (perindopril A/amlodipine) in a subgroup of 1936 people participating in the Russian observational CONSTANTA program, most cases of whom were given the drug as a substitute for earlier ineffective monotherapy and combination therapy, without using other antihyperterisive agents.<br />Subjects and Methods: The analysis included 1936 patients (aged 58.2±7.5 years; 35% men) with uncontrolled hypertension who received angiotensin-converting enzyme (ACE) inhibitors or angiotensin II (AT II) receptor antagonists alone or in conjunction with free or fixed-dose combinations of two-three antihypertensive agents and who were given Prestance to correct antihypertensive therapy, as decided by their doctors. The goal blood pressure (BP) was <140/<90 mm Hg for all the patients. Their treatment lasted three months.<br />Results: At the end of trial, the patients received Prestance (perindopril A/amlodipine) in the following doses: 5/5 mg (15% of the patients), 10/5 mg (39.9%), 5/10 mg (9.8%), 10/10 mg (36.6%). In the analyzed group, the baseline BP was 163.4±13.7/94.6+10,1 mm Hg; heart rate (HR), 74.0±10.9 beats/min; 3 months later, there were decreases in BP to 130.8±10.2/78.5±7.2 mm Hg (as compared to the baseline values; p<0.001) and in HR to 67.9?5.4 beats/min (p<0.01). The mean BP reduction was 32.6±10.8/16.1±7.2 mm Hg. A total of 1607 (83.0%) patients achieved the goal BP while 1520 (78.5%) patients did this without having another antihypertensive therapy.<br />Conclusion: To switch hypertensive patients receiving ineffective monotherapy or dual therapy using ACE inhibitors or AT II receptor blockers to fixed-dose perindopril A and amlodipine combination (Prestance) is a rational way of optimizing a therapy regimen in these patients with a wide range of baseline BP levels; moreover, four out of five patients did not need any additional antihypertensive drug.
- Subjects :
- Adult
Aged
Amlodipine administration & dosage
Antihypertensive Agents administration & dosage
Blood Pressure drug effects
Drug Combinations
Female
Heart Rate drug effects
Humans
Hypertension complications
Male
Middle Aged
Perindopril administration & dosage
Risk Factors
Russia
Treatment Outcome
Amlodipine therapeutic use
Antihypertensive Agents therapeutic use
Hypertension drug therapy
Perindopril therapeutic use
Subjects
Details
- Language :
- Russian
- ISSN :
- 0040-3660
- Volume :
- 87
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Terapevticheskii arkhiv
- Publication Type :
- Academic Journal
- Accession number :
- 26027243
- Full Text :
- https://doi.org/10.17116/terarkh201587366-70