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Preserved dendritic cell HLA-DR expression and reduced regulatory T cell activation in asymptomatic Plasmodium falciparum and P. vivax infection.
- Source :
-
Infection and immunity [Infect Immun] 2015 Aug; Vol. 83 (8), pp. 3224-32. Date of Electronic Publication: 2015 Jun 01. - Publication Year :
- 2015
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Abstract
- Clinical illness with Plasmodium falciparum or Plasmodium vivax compromises the function of dendritic cells (DC) and expands regulatory T (Treg) cells. Individuals with asymptomatic parasitemia have clinical immunity, restricting parasite expansion and preventing clinical disease. The role of DC and Treg cells during asymptomatic Plasmodium infection is unclear. During a cross-sectional household survey in Papua, Indonesia, we examined the number and activation of blood plasmacytoid DC (pDC), CD141(+), and CD1c(+) myeloid DC (mDC) subsets and Treg cells using flow cytometry in 168 afebrile children (of whom 15 had P. falciparum and 36 had P. vivax infections) and 162 afebrile adults (of whom 20 had P. falciparum and 20 had P. vivax infections), alongside samples from 16 patients hospitalized with uncomplicated malaria. Unlike DC from malaria patients, DC from children and adults with asymptomatic, microscopy-positive P. vivax or P. falciparum infection increased or retained HLA-DR expression. Treg cells in asymptomatic adults and children exhibited reduced activation, suggesting increased immune responsiveness. The pDC and mDC subsets varied according to clinical immunity (asymptomatic or symptomatic Plasmodium infection) and, in asymptomatic infection, according to host age and parasite species. In conclusion, active control of asymptomatic infection was associated with and likely contingent upon functional DC and reduced Treg cell activation.<br /> (Copyright © 2015, American Society for Microbiology. All Rights Reserved.)
- Subjects :
- Adolescent
Adult
Asymptomatic Diseases
Child
Child, Preschool
Cross-Sectional Studies
Down-Regulation
Female
Flow Cytometry
HLA-DR Antigens immunology
Humans
Indonesia
Lymphocyte Activation
Malaria, Falciparum diagnosis
Malaria, Falciparum immunology
Malaria, Falciparum parasitology
Malaria, Vivax diagnosis
Malaria, Vivax immunology
Malaria, Vivax parasitology
Male
Plasmodium falciparum immunology
Plasmodium vivax immunology
Young Adult
Dendritic Cells immunology
HLA-DR Antigens genetics
Malaria, Falciparum genetics
Malaria, Vivax genetics
Plasmodium falciparum physiology
Plasmodium vivax physiology
T-Lymphocytes, Regulatory immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1098-5522
- Volume :
- 83
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Infection and immunity
- Publication Type :
- Academic Journal
- Accession number :
- 26034211
- Full Text :
- https://doi.org/10.1128/IAI.00226-15