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A new and efficient synthesis of 6-O-methylscutellarein, the major metabolite of the natural medicine scutellarin.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2015 Jun 02; Vol. 20 (6), pp. 10184-91. Date of Electronic Publication: 2015 Jun 02. - Publication Year :
- 2015
-
Abstract
- In this paper, a new and efficient synthesis of 6-O-methylscutellarein (3), the major metabolite of the natural medicine scutellarin, is reported. Two hydroxyl groups at C-4' and C-7 in 2 were selectively protected by chloromethyl methyl ether after the reaction conditions were optimized, then 6-O-methyl-scutellarein (3) was produced in high yield after methylation of the hydroxyl group at C-6 and subsequent deprotection of the two methyl ether groups.
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 20
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 26042857
- Full Text :
- https://doi.org/10.3390/molecules200610184