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Shell Cross-Linked Polymeric Micelles as Camptothecin Nanocarriers for Anti-HCV Therapy.
- Source :
-
Macromolecular bioscience [Macromol Biosci] 2015 Oct; Vol. 15 (10), pp. 1381-91. Date of Electronic Publication: 2015 Jun 05. - Publication Year :
- 2015
-
Abstract
- A suitable carrier for camptothecin to act as therapy against the hepatitis C virus is presented. The carrier relies on an amphiphilic hybrid dendritic-linear-dendritic block copolymer, derived from pluronic F127 and bis-MPA dendrons, that forms micelles in aqueous solution. The dendrons admit the incorporation of multiple photoreactive groups that allow the clean and effective preparation of covalently cross-linked polymeric micelles (CLPM), susceptible of loading hydrophilic and lipophilic molecules. Cell-uptake experiments using a newly designed fluorophore, derived from rhodamine B, demonstrate that the carrier favors the accumulation of its cargo within the cell. Furthermore, loaded with camptothecin, it is efficient in fighting against the hepatitis C virus while shows lower cytotoxicity than the free drug.<br /> (© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Calorimetry
Cell Survival drug effects
Endocytosis drug effects
Fluorescent Dyes chemistry
HeLa Cells
Humans
Poloxamer chemical synthesis
Poloxamer chemistry
Surface-Active Agents chemistry
Virus Replication drug effects
Antiviral Agents pharmacology
Camptothecin pharmacology
Cross-Linking Reagents chemistry
Drug Carriers chemistry
Hepacivirus drug effects
Micelles
Nanoparticles chemistry
Polymers chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1616-5195
- Volume :
- 15
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Macromolecular bioscience
- Publication Type :
- Academic Journal
- Accession number :
- 26045353
- Full Text :
- https://doi.org/10.1002/mabi.201500094