Functional polymorphism rs710218 in the gene coding GLUT1 protein is associated with in-stent restenosis.

Authors :: Osadnik T
Strzelczyk J
Bujak K
Reguła R
Wasilewski J
Fronczek M
Kurek A
Gawlita M
Gonera M
Gierlotka M
Lekston A
Hawranek M
Myrda K
Wiczkowski A
Ostrowska Z
Gąsior M
Poloński L
Source :: Biomarkers in medicine [Biomark Med] 2015; Vol. 9 (8), pp. 743-50. Date of Electronic Publication: 2015 Jun 08.
Publication Year :: 2015
Abstract: Aim: To analyze the association between in-stent restenosis (ISR) and polymorphisms in genes coding IGF-1, IGFBP3, ITGB3 and GLUT1, which play an important role in the smooth muscle cell proliferation and extracellular matrix synthesis - the main components of neointima.<br />Materials & Methods: We analyzed 265 patients who underwent bare metal stent implantation.<br />Results: The differences in the occurrence of ISR between genotypes of the analyzed polymorphisms in the IGF-1, IGFBP3 and ITGB3 were not statistically significant. The T/T genotype of the rs710218 polymorphism in the GLUT1 (SLC2A1) gene was more common in the ISR group compared with non-ISR patients (81.1 vs 64.8%; p = 0.02). In a multivariable model the A/A and A/T genotype remained correlated with lower occurrence of ISR (odds ratio: 0.45; 95% CI: 0.21-0.97; p = 0.03).<br />Conclusion: The rs710218 polymorphism in the gene coding GLUT1 protein is a novel risk factor for ISR.

Subjects :: Aged
Female
Gene Frequency
Genotype
Humans
Insulin-Like Growth Factor Binding Protein 3 genetics
Insulin-Like Growth Factor I genetics
Integrin beta3 genetics
Male
Middle Aged
Multivariate Analysis
Coronary Restenosis genetics
Genetic Predisposition to Disease genetics
Glucose Transporter Type 1 genetics
Polymorphism, Single Nucleotide
Stents

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