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Genetic variants in microRNA genes: impact on microRNA expression, function, and disease.

Authors :
Cammaerts S
Strazisar M
De Rijk P
Del Favero J
Source :
Frontiers in genetics [Front Genet] 2015 May 21; Vol. 6, pp. 186. Date of Electronic Publication: 2015 May 21 (Print Publication: 2015).
Publication Year :
2015

Abstract

MicroRNAs (miRNAs) are important regulators of gene expression and like any other gene, their coding sequences are subject to genetic variation. Variants in miRNA genes can have profound effects on miRNA functionality at all levels, including miRNA transcription, maturation, and target specificity, and as such they can also contribute to disease. The impact of variants in miRNA genes is the focus of the present review. To put these effects into context, we first discuss the requirements of miRNA transcripts for maturation. In the last part an overview of available databases and tools and experimental approaches to investigate miRNA variants related to human disease is presented.

Details

Language :
English
ISSN :
1664-8021
Volume :
6
Database :
MEDLINE
Journal :
Frontiers in genetics
Publication Type :
Academic Journal
Accession number :
26052338
Full Text :
https://doi.org/10.3389/fgene.2015.00186