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Prevalence and clinical correlates of somatic mutation in aldosterone producing adenoma-Taiwanese population.
- Source :
-
Scientific reports [Sci Rep] 2015 Jun 12; Vol. 5, pp. 11396. Date of Electronic Publication: 2015 Jun 12. - Publication Year :
- 2015
-
Abstract
- Primary aldosteronism (PA) is a common form of secondary hypertension and has significant cardiovascular consequences. Mutated channelopathy due to the activation of calcium channels has been recently described in aldosterone-producing adenoma (APA). The study involved 148 consecutive PA patients, (66 males; aged 56.3 ± 12.3years) who received adrenalectomy, and were collected from the Taiwan PA investigator (TAIPAI) group. A high rate of somatic mutation in APA was found (n=91, 61.5%); including mutations in KCNJ5 (n=88, 59.5%), ATP1A1 (n=2, 1.4%), and ATP2B3 (n=1, 0.7%); however, no mutations in CACNA1D were identified. Mutation-carriers were younger (<0.001), had lower Cyst C (p=0.042), pulse wave velocity (p=0.027), C-reactive protein (p=0.042) and a lower rate of proteinuria (p=0.031) than non-carriers. After multivariate adjustment, mutation carriers had lower serum CRP levels than non-carriers (p=0.031. Patients with mutation also had a greater chance of recovery from hypertension after operation (p=0.005). A high incidence of somatic mutations in APA was identified in the Taiwanese population. Mutation-carriers had lower CRP levels and a higher rate of cure of hypertension after adrenalectomy. This raises the possibility of using mutation screening as a tool in predicting long-term outcome after adrenalectomy.
- Subjects :
- Adenoma blood
Adenoma epidemiology
Adult
Age Factors
Aged
Female
G Protein-Coupled Inwardly-Rectifying Potassium Channels metabolism
Humans
Hyperaldosteronism blood
Hyperaldosteronism epidemiology
Hyperaldosteronism genetics
Male
Middle Aged
Neoplasm Proteins metabolism
Plasma Membrane Calcium-Transporting ATPases metabolism
Prevalence
Sodium-Potassium-Exchanging ATPase metabolism
Taiwan epidemiology
Adenoma genetics
Aldosterone metabolism
G Protein-Coupled Inwardly-Rectifying Potassium Channels genetics
Mutation
Neoplasm Proteins genetics
Plasma Membrane Calcium-Transporting ATPases genetics
Sodium-Potassium-Exchanging ATPase genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 5
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 26066391
- Full Text :
- https://doi.org/10.1038/srep11396