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Cell encapsulation: technical and clinical advances.
- Source :
-
Trends in pharmacological sciences [Trends Pharmacol Sci] 2015 Aug; Vol. 36 (8), pp. 537-46. Date of Electronic Publication: 2015 Jun 08. - Publication Year :
- 2015
-
Abstract
- Treating many chronic diseases will require a tight, minute-to-minute regulation of therapeutic molecules that is currently not achievable with most pharmaceutical therapies. For these diseases, implantable living cellular systems may be able to provide unlimited drug delivery, enabling seamless matching of treatment duration with disease longevity. Cell encapsulation is an advanced technology that achieves this goal and represents a viable therapeutic option. The advanced state of the field has allowed researchers to inch forward into therapeutic domains previously untouchable because of the myriad disparate fields that intersect biomaterials and cells. Here, we discuss the next generation of clinical trials and potential approaches, 'smart' and responsive encapsulation systems, sophisticated and multifunctional devices, and novel imaging tools, together with the future challenges in the field.<br /> (Copyright © 2015 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1873-3735
- Volume :
- 36
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Trends in pharmacological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 26067102
- Full Text :
- https://doi.org/10.1016/j.tips.2015.05.003