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Effects of testosterone replacement therapy on nocturia and quality of life in men with hypogonadism: a subanalysis of a previous prospective randomized controlled study in Japan.
- Source :
-
The aging male : the official journal of the International Society for the Study of the Aging Male [Aging Male] 2015; Vol. 18 (3), pp. 169-74. Date of Electronic Publication: 2015 Jun 15. - Publication Year :
- 2015
-
Abstract
- Objective: We investigated the effects of testosterone replacement therapy (TRT) on nocturia and general health among men with hypogonadism and nocturia.<br />Methods: From our previous EARTH study population, 64 patients with a clinical diagnosis of nocturia (two or more times per one night) and hypogonadism, comprising the TRT group (n = 31) and controls (n = 33), were included in this analysis. The TRT group was administered 250 mg of testosterone enanthate as an intramuscular injection every 4 weeks for 6 months. All patients responded to the following questionnaires: International Prostatic Symptoms Score (IPSS), Aging Male Symptoms (AMS) score and Short Form-36 health survey at baseline and 6-month visit. These categories were compared based on changes from baseline to the 6-month visit between TRT and control groups.<br />Results: At the 6-month visit, the TRT group had a significant decrease in IPSS question no. 7 and AMS question no. 4, whereas no significant changes were observed in the control group. Additionally, role limitation because of health program, vitality and mental health domains were significantly improved in the TRT group.<br />Conclusions: Six-month TRT may improve nocturia, sleep conditions and quality of life among men with hypogonadism and nocturia.
- Subjects :
- Aged
Aged, 80 and over
Aging
Humans
Hypogonadism complications
Japan
Male
Middle Aged
Nocturia complications
Prospective Studies
Quality of Life
Surveys and Questionnaires
Testosterone administration & dosage
Androgens administration & dosage
Hormone Replacement Therapy
Hypogonadism drug therapy
Nocturia drug therapy
Testosterone analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1473-0790
- Volume :
- 18
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The aging male : the official journal of the International Society for the Study of the Aging Male
- Publication Type :
- Academic Journal
- Accession number :
- 26075538
- Full Text :
- https://doi.org/10.3109/13685538.2015.1038990