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An Anticancer Role of Hydrogen Sulfide in Human Gastric Cancer Cells.
- Source :
-
Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2015; Vol. 2015, pp. 636410. Date of Electronic Publication: 2015 May 11. - Publication Year :
- 2015
-
Abstract
- Hydrogen sulfide (H2S) can be synthesized in mammalian cells by cystathionine γ-lyase (CSE) and/or cystathionine β-synthase (CBS). Both CSE and CBS are expressed in rat gastric tissues but their role in human gastric neoplasia has been unclear. The aims of the present study were to detect CSE and CBS proteins in human gastric cancer and determine the effect of exogenous NaHS on the proliferation of gastric cancer cells. We found that both CSE and CBS proteins were expressed in human gastric cancer cells and upregulated in human gastric carcinoma mucosa compared with those in noncancerous gastric samples. NaHS induced apoptosis of gastric cancer cells by regulating apoptosis related proteins. Also, NaHS inhibited cancer cell migration and invasion. An antigastric cancer role of H2S is thus indicated.
- Subjects :
- Aged
Caspase 3 metabolism
Cell Cycle Proteins metabolism
Cell Line, Tumor
Cell Movement drug effects
Cystathionine beta-Synthase genetics
Cystathionine beta-Synthase metabolism
Cystathionine gamma-Lyase genetics
Cystathionine gamma-Lyase metabolism
Cytochromes c metabolism
Female
Gastric Mucosa metabolism
Humans
Male
Microscopy, Fluorescence
Middle Aged
Real-Time Polymerase Chain Reaction
Stomach Neoplasms metabolism
Up-Regulation
bcl-2-Associated X Protein metabolism
Antineoplastic Agents toxicity
Apoptosis drug effects
Hydrogen Sulfide toxicity
Stomach Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1942-0994
- Volume :
- 2015
- Database :
- MEDLINE
- Journal :
- Oxidative medicine and cellular longevity
- Publication Type :
- Academic Journal
- Accession number :
- 26078811
- Full Text :
- https://doi.org/10.1155/2015/636410