Back to Search Start Over

Influence of Anti-TNF and Disease Modifying Antirheumatic Drugs Therapy on Pulmonary Forced Vital Capacity Associated to Ankylosing Spondylitis: A 2-Year Follow-Up Observational Study.

Authors :
Rocha-Muñoz AD
Brambila-Tapia AJ
Zavala-Cerna MG
Vásquez-Jiménez JC
De la Cerda-Trujillo LF
Vázquez-Del Mercado M
Rodriguez-Jimenez NA
Díaz-Rizo V
Díaz-González V
Cardona-Muñoz EG
Dávalos-Rodríguez IP
Salazar-Paramo M
Gamez-Nava JI
Nava-Zavala AH
Gonzalez-Lopez L
Source :
Journal of immunology research [J Immunol Res] 2015; Vol. 2015, pp. 980147. Date of Electronic Publication: 2015 May 19.
Publication Year :
2015

Abstract

Objective: To evaluate the effect of anti-TNF agents plus synthetic disease modifying antirheumatic drugs (DMARDs) versus DMARDs alone for ankylosing spondylitis (AS) with reduced pulmonary function vital capacity (FVC%).<br />Methods: In an observational study, we included AS who had FVC% <80% at baseline. Twenty patients were taking DMARDs and 16 received anti-TNF + DMARDs.<br />Outcome Measures: changes in FVC%, BASDAI, BASFI, 6-minute walk test (6MWT), Borg scale after 6MWT, and St. George's Respiratory Questionnaire at 24 months.<br />Results: Both DMARDs and anti-TNF + DMARDs groups had similar baseline values in FVC%. Significant improvement was achieved with anti-TNF + DMARDs in FVC%, at 24 months, when compared to DMARDs alone (P = 0.04). Similarly, patients in anti-TNF + DMARDs group had greater improvement in BASDAI, BASFI, Borg scale, and 6MWT when compared to DMARDs alone. After 2 years of follow-up, 14/16 (87.5%) in the anti-TNF + DMARDs group achieved the primary outcome: FVC% ≥80%, compared with 11/20 (55%) in the DMARDs group (P = 0.04).<br />Conclusions: Patients with anti-TNF + DMARDs had a greater improvement in FVC% and cardiopulmonary scales at 24 months compared with DMARDs. This preliminary study supports the fact that anti-TNF agents may offer additional benefits compared to DMARDs in patients with AS who have reduced FVC%.

Details

Language :
English
ISSN :
2314-7156
Volume :
2015
Database :
MEDLINE
Journal :
Journal of immunology research
Publication Type :
Academic Journal
Accession number :
26078986
Full Text :
https://doi.org/10.1155/2015/980147