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Benchmarking biomarker-based criteria for Alzheimer's disease: Data from the Swedish Dementia Registry, SveDem.
- Source :
-
Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2015 Dec; Vol. 11 (12), pp. 1470-1479. Date of Electronic Publication: 2015 Jun 13. - Publication Year :
- 2015
-
Abstract
- Introduction: New research guidelines for the diagnosis of Alzheimer's disease (AD) include biomarker evidence of amyloid-β (Aβ) and tau pathology. The aim of this study was to investigate what proportion of AD patients diagnosed in clinical routine in Sweden that had an AD-indicative cerebrospinal fluid (CSF) biomarker profile.<br />Methods: By cross-referencing a laboratory database with the Swedish Dementia Registry (SveDem), 2357 patients with data on CSF Aβ and tau biomarkers and a clinical diagnosis of AD with dementia were acquired.<br />Results: Altogether, 77.2% had pathologic Aβ42 and total tau or phosphorylated tau in CSF. These results were stable across age groups. Female sex and low mini-mental state examination score increased the likelihood of pathologic biomarkers.<br />Discussion: About a quarter of clinically diagnosed AD patients did not have an AD-indicative CSF biomarker profile. This discrepancy may partly reflect incorrect (false positive) clinical diagnosis or a lack in sensitivity of the biomarker assays.<br /> (Copyright © 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Aged
Aged, 80 and over
Amyloid beta-Peptides cerebrospinal fluid
Female
Humans
Male
Middle Aged
Peptide Fragments cerebrospinal fluid
Phosphorylation
Registries
Sex Factors
Sweden
tau Proteins cerebrospinal fluid
Alzheimer Disease cerebrospinal fluid
Benchmarking methods
Biomarkers cerebrospinal fluid
Subjects
Details
- Language :
- English
- ISSN :
- 1552-5279
- Volume :
- 11
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Alzheimer's & dementia : the journal of the Alzheimer's Association
- Publication Type :
- Academic Journal
- Accession number :
- 26079415
- Full Text :
- https://doi.org/10.1016/j.jalz.2015.04.007