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Passive targeting of thermosensitive diblock copolymer micelles to the lungs: synthesis and characterization of poly(N-isopropylacrylamide)-block-poly(ε-caprolactone).
- Source :
-
Journal of nanobiotechnology [J Nanobiotechnology] 2015 Jun 18; Vol. 13, pp. 42. Date of Electronic Publication: 2015 Jun 18. - Publication Year :
- 2015
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Abstract
- Background: Amphiphilic poly(N-isopropylacrylamide)-block-poly(ε-caprolactone) (PNiPAAm-b-PCL) copolymers were synthesized by ring-opening polymerization to form thermosensitive micelles as nanocarriers for bioimaging and carboplatin delivery.<br />Results: The critical micelle concentration increased from 1.8 to 3.5 mg/l following the decrease of the PNiPAAm chain length. The copolymers revealed a lower critical solution temperature (LCST) between 33 and 40°C. The copolymers self-assembled to form spherical particles of 146-199 nm in diameter. Carboplatin in micelles exhibited a slower release at 37°C relative to that at 25°C due to the gel layer formation on the micellar shell above the LCST. The micelles containing dye or carboplatin were intravenously injected into the rats for in vivo bioimaging and drug biodistribution. The bioimaging profiles showed a significant accumulation of micelles in the lungs. The micelles could minimize the reticuloendothelial system (RES) recognition of the dye. In vivo biodistribution demonstrated an improved pulmonary accumulation of carboplatin from 2.5 to 3.4 μg/mg by the micelles as compared to the control solution. Carboplatin accumulation in the heart and kidneys was reduced after encapsulation by the micelles.<br />Conclusion: This study supports the potential of PNiPAAm-b-PCL micelles to passively target the lungs and attenuate RES uptake and possible side effects.
- Subjects :
- Adult
Animals
Caproates chemistry
Carboplatin chemistry
Carboplatin pharmacokinetics
Drug Carriers pharmacokinetics
HEK293 Cells drug effects
Humans
Kidney drug effects
L-Lactate Dehydrogenase metabolism
Lactones chemistry
Lung drug effects
Magnetic Resonance Spectroscopy
Male
Micelles
Neutrophils drug effects
Neutrophils metabolism
Rats, Sprague-Dawley
Spectroscopy, Fourier Transform Infrared
Temperature
Tissue Distribution
Acrylic Resins administration & dosage
Acrylic Resins chemistry
Carboplatin administration & dosage
Drug Carriers administration & dosage
Drug Carriers chemistry
Polyesters administration & dosage
Polyesters chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1477-3155
- Volume :
- 13
- Database :
- MEDLINE
- Journal :
- Journal of nanobiotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 26084491
- Full Text :
- https://doi.org/10.1186/s12951-015-0103-7