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ABCG2 gene polymorphisms as risk factors for atorvastatin adverse reactions: a case-control study.
- Source :
-
Pharmacogenomics [Pharmacogenomics] 2015 Jul; Vol. 16 (8), pp. 803-15. Date of Electronic Publication: 2015 Jun 18. - Publication Year :
- 2015
-
Abstract
- Aim: To explore the association between dose-related adverse drug reactions (ADRs) of atorvastatin and polymorphisms of ABCG2, taking into account the influence of CYP3A4 and SLCO1B1 genes.<br />Materials & Methods: Sixty patients who experienced atorvastatin dose-related ADRs and 90 matched patients without ADRs were enrolled in the study. Genotyping for ABCG2 421C > A, CYP3A4*22, SLCO1B1 388A > G, SLCO1B1 521T > C variants was performed by real-time PCR.<br />Results: Patients with ABCG2 421CA or AA genotypes had 2.9 times greater odds of developing atorvastatin dose-dependent ADRs (OR: 2.91; 95% CI: 1.22-6.95; p = 0.016) than those with ABCG2 421CC genotype. After adjustments for clinical and genetic risk factors, ABCG2 remained a statistically significant predictor of adverse drug reactions (OR: 2.75; 95% CI: 1.1-6.87; p = 0.03;). Also, carriers of SLCO1B1 521 TC or CC genotypes had 2.3 greater odds (OR: 1.03-4.98; 95% CI: 1.03-4.98; p = 0.043) of experiencing ADRs caused by atorvastatin in comparison with carriers of SLCO1B1 521 TT genotype.<br />Conclusion: Our study demonstrated an association between atorvastatin-induced ADRs and genetic variants in the ABCG2 gene.
- Subjects :
- ATP Binding Cassette Transporter, Subfamily G, Member 2
Adult
Asian People
Cytochrome P-450 CYP3A genetics
Female
Genotype
Humans
Liver-Specific Organic Anion Transporter 1
Male
Middle Aged
Organic Anion Transporters genetics
Polymorphism, Single Nucleotide
Risk Factors
ATP-Binding Cassette Transporters genetics
Atorvastatin adverse effects
Drug-Related Side Effects and Adverse Reactions genetics
Genetic Association Studies
Neoplasm Proteins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1744-8042
- Volume :
- 16
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Pharmacogenomics
- Publication Type :
- Academic Journal
- Accession number :
- 26086347
- Full Text :
- https://doi.org/10.2217/pgs.15.47