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Crosstalk between the nociceptive and immune systems in host defence and disease.
- Source :
-
Nature reviews. Neuroscience [Nat Rev Neurosci] 2015 Jul; Vol. 16 (7), pp. 389-402. - Publication Year :
- 2015
-
Abstract
- Nociceptors and immune cells both protect the host from potential threats to homeostasis. There is growing evidence for bidirectional signalling between these two systems, and the underlying mechanisms are beginning to be elucidated. An understanding is emerging of how both the adaptive and innate immune systems can activate and sensitize nociceptors, and, reciprocally, how nociceptors modulate immune cells. In this Review, we discuss how these interactions can be adaptive and useful to the organism but also consider when such signalling might be maladaptive and pathophysiological, contributing to immune-mediated diseases and persistent pain states.
- Subjects :
- Animals
Humans
Immune System immunology
Immune System metabolism
Immune System Diseases immunology
Immune System Diseases metabolism
Nociceptors metabolism
Pain immunology
Pain metabolism
Adaptive Immunity immunology
Host Specificity immunology
Immunity, Cellular immunology
Immunity, Innate immunology
Nociceptors immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1471-0048
- Volume :
- 16
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Nature reviews. Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 26087680
- Full Text :
- https://doi.org/10.1038/nrn3946