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Detection of human parvovirus 4 viremia in the follow-up blood samples from seropositive individuals suggests the existence of persistent viral replication or reactivation of latent viral infection.

Authors :
Chen MY
Hung CC
Lee KL
Source :
Virology journal [Virol J] 2015 Jun 19; Vol. 12, pp. 94. Date of Electronic Publication: 2015 Jun 19.
Publication Year :
2015

Abstract

Background: The transmission routes for human parvovirus 4 (PARV4) infections in areas with high seroprevalence are not known. In the work described here, persistent PARV4 viral replication was investigated by conducting a longitudinal study.<br />Methods: Ten healthcare workers each provided a blood sample at the beginning of the study (first sample) and 12 months later (second sample). The paired samples were tested for PARV4-positivity by immunoblotting analysis and nested polymerase chain reactions.<br />Results: IgG antibodies against PARV4 were detected in six participants, three of whom also had IgM antibodies against PARV4. The immunoblotting results did not vary over time. PARV4 DNA was detected in the first blood sample from one participant who had IgG antibodies against PARV4 and in the second blood samples from 2 participants who had IgG and IgM antibodies against PARV4.<br />Conclusions: Detection of PARV4 DNA in the second blood samples from two seropositive participants suggests the existence of persistent PARV4 replication or reactivation of inactive virus in the tissues. The finding of persistent or intermittent PARV4 replication in individuals with past infections provides an important clue toward unraveling the non-parenteral transmission routes of PARV4 infection in areas where the virus is endemic.

Details

Language :
English
ISSN :
1743-422X
Volume :
12
Database :
MEDLINE
Journal :
Virology journal
Publication Type :
Academic Journal
Accession number :
26088443
Full Text :
https://doi.org/10.1186/s12985-015-0326-0