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Characterizing Race/Ethnicity and Genetic Ancestry for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort.

Authors :
Banda Y
Kvale MN
Hoffmann TJ
Hesselson SE
Ranatunga D
Tang H
Sabatti C
Croen LA
Dispensa BP
Henderson M
Iribarren C
Jorgenson E
Kushi LH
Ludwig D
Olberg D
Quesenberry CP Jr
Rowell S
Sadler M
Sakoda LC
Sciortino S
Shen L
Smethurst D
Somkin CP
Van Den Eeden SK
Walter L
Whitmer RA
Kwok PY
Schaefer C
Risch N
Source :
Genetics [Genetics] 2015 Aug; Vol. 200 (4), pp. 1285-95. Date of Electronic Publication: 2015 Jun 19.
Publication Year :
2015

Abstract

Using genome-wide genotypes, we characterized the genetic structure of 103,006 participants in the Kaiser Permanente Northern California multi-ethnic Genetic Epidemiology Research on Adult Health and Aging Cohort and analyzed the relationship to self-reported race/ethnicity. Participants endorsed any of 23 race/ethnicity/nationality categories, which were collapsed into seven major race/ethnicity groups. By self-report the cohort is 80.8% white and 19.2% minority; 93.8% endorsed a single race/ethnicity group, while 6.2% endorsed two or more. Principal component (PC) and admixture analyses were generally consistent with prior studies. Approximately 17% of subjects had genetic ancestry from more than one continent, and 12% were genetically admixed, considering only nonadjacent geographical origins. Self-reported whites were spread on a continuum along the first two PCs, indicating extensive mixing among European nationalities. Self-identified East Asian nationalities correlated with genetic clustering, consistent with extensive endogamy. Individuals of mixed East Asian-European genetic ancestry were easily identified; we also observed a modest amount of European genetic ancestry in individuals self-identified as Filipinos. Self-reported African Americans and Latinos showed extensive European and African genetic ancestry, and Native American genetic ancestry for the latter. Among 3741 genetically identified parent-child pairs, 93% were concordant for self-reported race/ethnicity; among 2018 genetically identified full-sib pairs, 96% were concordant; the lower rate for parent-child pairs was largely due to intermarriage. The parent-child pairs revealed a trend toward increasing exogamy over time; the presence in the cohort of individuals endorsing multiple race/ethnicity categories creates interesting challenges and future opportunities for genetic epidemiologic studies.<br /> (Copyright © 2015 by the Genetics Society of America.)

Details

Language :
English
ISSN :
1943-2631
Volume :
200
Issue :
4
Database :
MEDLINE
Journal :
Genetics
Publication Type :
Academic Journal
Accession number :
26092716
Full Text :
https://doi.org/10.1534/genetics.115.178616