Reversal of a Single Base-Pair Step Controls Guanine Photo-Oxidation by an Intercalating Ruthenium(II) Dipyridophenazine Complex.

Authors :: Keane PM
Poynton FE
Hall JP
Sazanovich IV
Towrie M
Gunnlaugsson T
Quinn SJ
Cardin CJ
Kelly JM
Source :: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2015 Jul 13; Vol. 54 (29), pp. 8364-8. Date of Electronic Publication: 2015 Jun 11.
Publication Year :: 2015
Abstract: Small changes in DNA sequence can often have major biological effects. Here the rates and yields of guanine photo-oxidation by Λ-[Ru(TAP)2(dppz)](2+) have been compared in 5'-{CCGGATCCGG}2 and 5'-{CCGGTACCGG}2 using pico/nanosecond transient visible and time-resolved IR (TRIR) spectroscopy. The inefficiency of electron transfer in the TA sequence is consistent with the 5'-TA-3' versus 5'-AT-3' binding preference predicted by X-ray crystallography. The TRIR spectra also reveal the differences in binding sites in the two oligonucleotides.<br /> (© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Subjects :: Base Pairing
Base Sequence
Coordination Complexes chemistry
Crystallography, X-Ray
Intercalating Agents chemistry
Light
Models, Molecular
Oxidation-Reduction drug effects
Phenazines chemistry
Ruthenium chemistry
Coordination Complexes pharmacology
DNA chemistry
Guanine chemistry
Intercalating Agents pharmacology
Phenazines pharmacology
Ruthenium pharmacology

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