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Dyslipidaemia in overweight children and adolescents is associated with an increased risk of kidney stones.
- Source :
-
Acta paediatrica (Oslo, Norway : 1992) [Acta Paediatr] 2015 Sep; Vol. 104 (9), pp. e407-13. Date of Electronic Publication: 2015 Jul 22. - Publication Year :
- 2015
-
Abstract
- Aim: There is conflicting evidence about the role of obesity in paediatric nephrolithiasis. This Polish study explored the influence of nutritional status and lipid disturbances on urinary lithogenic factors and the risk of kidney stone formation in children and adolescents from three to 18 years of age.<br />Methods: We carried out serum lipid profile evaluations and 24-h urine chemistry analyses on 493 overweight/obese paediatric participants (mean age 13 years) without nephrolithiasis and 492 healthy normal weight sex and age-matched controls.<br />Results: A third (33%) of the study group had blood lipid disturbances, with more acidic urine, lower urinary citrate excretion and a higher fraction of ionised calcium and higher Bonn Risk Index than the controls. The participants' body mass index standard deviation score (BMI Z-score) was positively correlated with urinary oxalate and uric acid and negatively correlated with citrate excretion. Total cholesterol, low-density lipoprotein cholesterol and triglycerides correlated negatively with citraturia, while high-density lipoprotein cholesterol correlated positively.<br />Conclusion: The main factor that predisposed overweight and obese children to kidney stones was hypocitraturia. Urinary citrate excretion was related to both BMI Z-scores and all lipid fraction abnormalities. However, hypercholesterolaemia and particularly low-density lipoprotein hypercholesterolaemia seemed to play a major role.<br /> (©2015 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.)
- Subjects :
- Adolescent
Body Mass Index
Calcium urine
Case-Control Studies
Child
Child, Preschool
Citric Acid urine
Cross-Sectional Studies
Female
Humans
Male
Nutritional Status
Oxalates urine
Poland
Prospective Studies
Risk Factors
Uric Acid urine
Dyslipidemias complications
Dyslipidemias metabolism
Kidney Calculi etiology
Obesity complications
Obesity metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1651-2227
- Volume :
- 104
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Acta paediatrica (Oslo, Norway : 1992)
- Publication Type :
- Academic Journal
- Accession number :
- 26096629
- Full Text :
- https://doi.org/10.1111/apa.13079