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S100B brain expression and plasma concentrations in a preeclampsia rat model.

S100B brain expression and plasma concentrations in a preeclampsia rat model.

Authors :
van Ijsselmuiden MN
Wiegman MJ
Zeeman GG
Faas MM
Source :
Pregnancy hypertension [Pregnancy Hypertens] 2011 Apr; Vol. 1 (2), pp. 143-9. Date of Electronic Publication: 2011 Feb 12.
Publication Year :
2011

Abstract

Objective: To assess brain damage using the neuroinflammation marker S100B in a preeclampsia rat model.<br />Methods: Non-pregnant and pregnant rats were infused with saline or low-dose-endotoxin on day 14 of pregnancy. S100B expression in the brain (immunohistochemistry) and S100B plasma concentrations (ELISA) were studied.<br />Results: No differences in S100B expression in brain tissue were observed between the four groups. Pregnant endotoxin treated animals did not show increased levels of plasma S100B levels as compared with control pregnant rats, while significantly higher plasma S100B levels were found in non-pregnant endotoxin versus pregnant endotoxin infused rats.<br />Conclusion: Pregnancy nor experimental preeclampsia, alter S100B in rat brain, or in plasma. Increased plasma S100B in non-pregnant endotoxin-treated rats may indicate brain injury in these rats, whereas pregnancy might be protective.<br /> (Copyright © 2011 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
2210-7789
Volume :
1
Issue :
2
Database :
MEDLINE
Journal :
Pregnancy hypertension
Publication Type :
Academic Journal
Accession number :
26104495
Full Text :
https://doi.org/10.1016/j.preghy.2011.01.007