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Divergent brain functional network alterations in dementia with Lewy bodies and Alzheimer's disease.
- Source :
-
Neurobiology of aging [Neurobiol Aging] 2015 Sep; Vol. 36 (9), pp. 2458-67. Date of Electronic Publication: 2015 Jun 02. - Publication Year :
- 2015
-
Abstract
- The clinical phenotype of dementia with Lewy bodies (DLB) is different from Alzheimer's disease (AD), suggesting a divergence between these diseases in terms of brain network organization. To fully understand this, we studied functional networks from resting-state functional magnetic resonance imaging in cognitively matched DLB and AD patients. The DLB group demonstrated a generalized lower synchronization compared with the AD and healthy controls, and this was more severe for edges connecting distant brain regions. Global network measures were significantly different between DLB and AD. For instance, AD showed lower small-worldness than healthy controls, while DLB showed higher small-worldness (AD < controls < DLB), and this was also the case for global efficiency (DLB > controls > AD) and clustering coefficient (DLB < controls < AD). Differences were also found for nodal measures at brain regions associated with each disease. Finally, we found significant associations between network performance measures and global cognitive impairment and severity of cognitive fluctuations in DLB. These results show network divergences between DLB and AD which appear to reflect their neuropathological differences.<br /> (Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Aged
Aged, 80 and over
Brain blood supply
Cohort Studies
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Mental Status Schedule
Nerve Net blood supply
Oxygen blood
Statistics, Nonparametric
Alzheimer Disease pathology
Brain pathology
Connectome
Lewy Body Disease pathology
Nerve Net pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1558-1497
- Volume :
- 36
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Neurobiology of aging
- Publication Type :
- Academic Journal
- Accession number :
- 26115566
- Full Text :
- https://doi.org/10.1016/j.neurobiolaging.2015.05.015