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Opposing Roles of Dectin-1 Expressed on Human Plasmacytoid Dendritic Cells and Myeloid Dendritic Cells in Th2 Polarization.
- Source :
-
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2015 Aug 15; Vol. 195 (4), pp. 1723-31. Date of Electronic Publication: 2015 Jun 29. - Publication Year :
- 2015
-
Abstract
- Dendritic cells (DCs) can induce and control host immune responses. DC subset-dependent functional specialties and their ability to display functional plasticity, which is mainly driven by signals via pattern recognition receptors, identify DCs as immune orchestrators. A pattern recognition receptor, Dectin-1, is expressed on myeloid DCs and known to play important roles in Th17 induction and activation during fungal and certain bacterial infections. In this study, we first demonstrate that human plasmacytoid DCs express Dectin-1 in both mRNA and protein levels. More interestingly, Dectin-1-activated plasmacytoid DCs promote Th2-type T cell responses, whereas Dectin-1-activated myeloid DCs decrease Th2-type T cell responses. Such contrasting outcomes of Th2-type T cell responses by the two DC subsets are mainly due to their distinct abilities to control surface OX40L expression in response to β-glucan. This study provides new insights for the regulation of host immune responses by Dectin-1 expressed on DCs.<br /> (Copyright © 2015 by The American Association of Immunologists, Inc.)
- Subjects :
- Cytokines biosynthesis
Dendritic Cells immunology
Humans
Immunologic Memory
Influenza A virus immunology
Intracellular Signaling Peptides and Proteins metabolism
Lectins, C-Type chemistry
Lectins, C-Type metabolism
Molecular Sequence Data
Myeloid Cells immunology
OX40 Ligand metabolism
Palatine Tonsil cytology
Palatine Tonsil immunology
Palatine Tonsil metabolism
Protein Binding
Protein-Tyrosine Kinases metabolism
RNA, Messenger genetics
RNA, Messenger metabolism
Spleen cytology
Spleen immunology
Spleen metabolism
Syk Kinase
T-Lymphocyte Subsets immunology
T-Lymphocyte Subsets metabolism
Th2 Cells immunology
beta-Glucans metabolism
Dendritic Cells metabolism
Gene Expression
Lectins, C-Type genetics
Myeloid Cells metabolism
Th2 Cells metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1550-6606
- Volume :
- 195
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of immunology (Baltimore, Md. : 1950)
- Publication Type :
- Academic Journal
- Accession number :
- 26123355
- Full Text :
- https://doi.org/10.4049/jimmunol.1402276