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Altered trabecular bone morphology in adolescent and young adult athletes with menstrual dysfunction.
- Source :
-
Bone [Bone] 2015 Dec; Vol. 81, pp. 24-30. Date of Electronic Publication: 2015 Jun 27. - Publication Year :
- 2015
-
Abstract
- Context: Young amenorrheic athletes (AA) have lower bone mineral density (BMD) and an increased prevalence of fracture compared with eumenorrheic athletes (EA) and non-athletes. Trabecular morphology is a determinant of skeletal strength and may contribute to fracture risk.<br />Objectives: To determine the variation in trabecular morphology among AA, EA, and non-athletes and to determine the association of trabecular morphology with fracture among AA.<br />Design and Setting: A cross-sectional study performed at an academic clinical research center.<br />Participants: 161 girls and young women aged 14-26 years (97 AA, 32 EA, and 32 non-athletes).<br />Main Outcome Measure: We measured volumetric BMD (vBMD) and skeletal microarchitecture using high-resolution peripheral quantitative computed tomography. We evaluated trabecular morphology (plate-like vs. rod-like), orientation, and connectivity by individual trabecula segmentation.<br />Results: At the non-weight-bearing distal radius, the groups did not differ for trabecular vBMD. However, plate-like trabecular bone volume fraction (pBV/TV) was lower in AA vs. EA (p=0.03), as were plate number (p=0.03) and connectivity (p=0.03). At the weight-bearing distal tibia, trabecular vBMD was higher in athletes vs. non-athletes (p=0.05 for AA and p=0.009 for EA vs. non-athletes, respectively). pBV/TV was higher in athletes vs. non-athletes (p=0.04 AA and p=0.005 EA vs. non-athletes), as were axially-aligned trabeculae, plate number, and connectivity. Among AA, those with a history of recurrent stress fracture had lower pBV/TV, axially-aligned trabeculae, plate number, plate thickness, and connectivity at the distal radius.<br />Conclusions: Trabecular morphology and alignment differ among AA, EA, and non-athletes. These differences may be associated with increased fracture risk.<br /> (Copyright © 2015. Published by Elsevier Inc.)
- Subjects :
- Adolescent
Adult
Bone Density physiology
Bone and Bones diagnostic imaging
Cross-Sectional Studies
Female
Finite Element Analysis
Fractures, Stress diagnostic imaging
Fractures, Stress epidemiology
Humans
Radiographic Image Interpretation, Computer-Assisted
Tomography, X-Ray Computed
Young Adult
Amenorrhea complications
Athletes
Bone and Bones pathology
Fractures, Stress etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2763
- Volume :
- 81
- Database :
- MEDLINE
- Journal :
- Bone
- Publication Type :
- Academic Journal
- Accession number :
- 26123592
- Full Text :
- https://doi.org/10.1016/j.bone.2015.06.021