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Recent Clinical Manifestation and Prognosis of Fungal Endophthalmitis: A 7-Year Experience at a Tertiary Referral Center in Korea.
- Source :
-
Journal of Korean medical science [J Korean Med Sci] 2015 Jul; Vol. 30 (7), pp. 960-4. Date of Electronic Publication: 2015 Jun 10. - Publication Year :
- 2015
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Abstract
- This study analyzed the recent causes, prognosis, and treatment strategies for fungal endophthalmitis. A retrospective review of patients who were diagnosed with fungal endophthalmitis at our center was conducted. The fungal organisms isolated from each patient and the visual prognosis according to the route of infection and treatment method were analyzed. A total of 40 eyes from 30 patients with fungal endophthalmitis were included in this study. Candida species were the most common causative organisms in 35 of 40 eyes. Endogenous and exogenous endophthalmitis were observed in 33 and 7 eyes, respectively. Pre- and post-treatment best-corrected visual acuity (BCVA) was not significantly different between endogenous endophthalmitis and exogenous endophthalmitis. The 40 eyes were treated using the following modalities: intravitreal antifungal agent injection with intravenous antifungal agent (16 eyes), vitrectomy with intravenous antifungal agent (14 eyes), intravenous antifungal agent alone (9 eyes), and evisceration (1 eye). Post-treatment BCVA only significantly improved after treatment in the vitrectomy group. Candida species were the most common cause of fungal endophthalmitis, irrespective of the route of infection. The visual prognosis of fungal endophthalmitis was generally poor. In conclusion, if the general condition of the patient tolerates a surgical procedure, prompt vitrectomy and intravitreal injection of antifungal agents can improve visual acuity.
- Subjects :
- Aspergillus isolation & purification
Endophthalmitis pathology
Endophthalmitis surgery
Eye Infections, Fungal
Fusarium isolation & purification
Humans
Prognosis
Republic of Korea
Retrospective Studies
Scedosporium isolation & purification
Tertiary Care Centers
Visual Acuity
Antifungal Agents therapeutic use
Candida isolation & purification
Endophthalmitis drug therapy
Endophthalmitis microbiology
Vitrectomy
Subjects
Details
- Language :
- English
- ISSN :
- 1598-6357
- Volume :
- 30
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of Korean medical science
- Publication Type :
- Academic Journal
- Accession number :
- 26130961
- Full Text :
- https://doi.org/10.3346/jkms.2015.30.7.960