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Occupational sensitization to lactase in the dietary supplement industry.
- Source :
-
Archives of environmental & occupational health [Arch Environ Occup Health] 2016 Sep 02; Vol. 71 (5), pp. 259-267. Date of Electronic Publication: 2015 Jul 02. - Publication Year :
- 2016
-
Abstract
- Aerogen lactase exposure carries a risk for the development of allergic asthma and rhinitis; only a few occupationally affected patients have been reported. The authors report the results of allergy testing with employees of a lactase tablets manufacturing plant. The survey involved 13 workers, including a questionnaire, spirometry, basophil activation test (BAT), and skin prick tests (SPTs) with lactase and a panel of common aeroallergens. Furthermore, lactase-specific immunoglobulin E (IgE) antibodies were analyzed. Sensitization to lactase could be proven for 9 workers by SPT and BAT; specific IgE antibodies could be detected in serum samples of all sensitized. However, IgE levels ≥0.35 kU/L were only found in 4 sera. These data confirm that occupational exposure to lactase can induce IgE-mediated respiratory sensitization resulting in allergic diseases. Protective measures should thus be obligatory when working with lactase.
Details
- Language :
- English
- ISSN :
- 2154-4700
- Volume :
- 71
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Archives of environmental & occupational health
- Publication Type :
- Academic Journal
- Accession number :
- 26134755
- Full Text :
- https://doi.org/10.1080/19338244.2015.1066294