" In situ " vaccination for systemic effects in follicular lymphoma.

Authors :: Kolstad A
Olweus J
Source :: Oncoimmunology [Oncoimmunology] 2015 Mar 19; Vol. 4 (7), pp. e1014773. Date of Electronic Publication: 2015 Mar 19 (Print Publication: 2015).
Publication Year :: 2015
Abstract: Therapeutic vaccines for follicular lymphoma have had limited success. A novel in situ immunotherapeutic strategy combining 3 different treatment modalities induced regression of disseminated follicular lymphoma, which correlated with systemic antitumor T-cell immunity. These results should renew interest in the development of local combined radio- and immunotherapies to achieve abscopal effects.