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MicroRNA-34c-5p is related to recurrence in laryngeal squamous cell carcinoma.
- Source :
-
The Laryngoscope [Laryngoscope] 2015 Sep; Vol. 125 (9), pp. E306-12. Date of Electronic Publication: 2015 Jul 07. - Publication Year :
- 2015
-
Abstract
- Objectives/hypothesis: Altered microRNA expression has been found in many cancer types, including laryngeal squamous cell carcinoma (LSCC). We investigated the association of LSCC-related miR-34c-5p with disease-free survival and overall survival.<br />Study Design: Retrospective cohort study.<br />Methods: Expression levels of miR-34c-5p were detected in 90 LSCC formalin-fixed paraffin-embedded tissues by reverse-transcription quantitative polymerase chain reaction. Overall survival and disease-free survival were evaluated using the Kaplan-Meier method, and multivariate analysis was performed using Cox proportional hazard analysis.<br />Results: A downregulation of miR-34c-5p expression significantly correlated with worse disease-free and overall survival. In the multivariate analysis, low miR-34c-5p expression was associated with an increased risk of recurrence.<br />Conclusions: A downregulation of miR-34c-5p in LSCC is independently associated with unfavorable disease-free survival, suggesting that miR-34c-5p might be a promising marker for evaluating the risk of recurrences.<br />Level of Evidence: NA.<br /> (© 2015 The American Laryngological, Rhinological and Otological Society, Inc.)
- Subjects :
- Aged
Aged, 80 and over
Carcinoma, Squamous Cell mortality
Carcinoma, Squamous Cell pathology
Female
Follow-Up Studies
Humans
Italy epidemiology
Laryngeal Neoplasms mortality
Laryngeal Neoplasms pathology
Male
Middle Aged
Neoplasm Recurrence, Local mortality
Neoplasm Recurrence, Local pathology
Neoplasm Staging
Prognosis
Real-Time Polymerase Chain Reaction
Retrospective Studies
Carcinoma, Squamous Cell genetics
Gene Expression Regulation, Neoplastic
Laryngeal Neoplasms genetics
MicroRNAs genetics
Neoplasm Recurrence, Local genetics
RNA, Neoplasm genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1531-4995
- Volume :
- 125
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- The Laryngoscope
- Publication Type :
- Academic Journal
- Accession number :
- 26153151
- Full Text :
- https://doi.org/10.1002/lary.25475