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Apparent diffusion coefficient parametric response mapping MRI for follow-up of glioblastoma.
- Source :
-
European radiology [Eur Radiol] 2016 Apr; Vol. 26 (4), pp. 1037-47. Date of Electronic Publication: 2015 Jul 10. - Publication Year :
- 2016
-
Abstract
- Objectives: To determine the diagnostic superiority of parametric response mapping of apparent diffusion coefficient (ADCPR) for predicting glioblastoma treatment response, compared to single time point measurement.<br />Methods: Fifty post-treatment glioblastoma patients were enrolled. ADCPR was calculated from serial apparent diffusion coefficient (ADC) maps acquired before and at the time of first detection of an enlarged contrast-enhancing lesion on voxel-by-voxel basis. The percentage-decrease in ADCPR and tenth percentile histogram cutoff value of ADC (ADC10) were compared at subsequent 3-month and 1-year follow-ups.<br />Results: The percentage-decrease in ADCPR was significantly higher in the progression group (mean = 33.2-38.3 %) than in the stable-response group (mean = 9.7 %) at 3 months follow-up (corrected p < 0.001 for both readers). ADCPR significantly improved area under the receiver operating characteristic curve from 0.67 to 0.88 (corrected p = 0.037) and from 0.70 to 0.92 (corrected p = 0.020) for both readers, respectively, compared to ADC10 at 3-month follow-up, but did not significantly improve at 1-year follow-up. The inter-reader agreement was higher for ADCPR than ADC10 (intraclass correlation coefficient, 0.93 versus 0.86).<br />Conclusion: Voxel-based ADCPR appears to be a superior imaging biomarker than ADC, particularly for predicting early tumour progression in patients with glioblastoma.<br />Key Points: • Treatment response pattern of glioblastoma was evaluated using voxel-based ADCPR and ADC10. • Voxel-based ADCPR was more accurate in predicting treatment response pattern than ADC10. • Inter-reader agreement was higher in ADCPR calculation than in ADC10 calculation. • Voxel-based ADCPR can be a predictor of early treatment response pattern for glioblastoma.
- Subjects :
- Adult
Aged
Aged, 80 and over
Brain Neoplasms therapy
Female
Follow-Up Studies
Glioblastoma therapy
Humans
Male
Middle Aged
ROC Curve
Reproducibility of Results
Retrospective Studies
Treatment Outcome
Brain Mapping methods
Brain Neoplasms pathology
Glioblastoma pathology
Magnetic Resonance Imaging methods
Subjects
Details
- Language :
- English
- ISSN :
- 1432-1084
- Volume :
- 26
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- European radiology
- Publication Type :
- Academic Journal
- Accession number :
- 26159871
- Full Text :
- https://doi.org/10.1007/s00330-015-3896-8