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Initial experience of radiotherapy plus cetuximab for Japanese head and neck cancer patients.
- Source :
-
Journal of radiation research [J Radiat Res] 2015 Sep; Vol. 56 (5), pp. 849-55. Date of Electronic Publication: 2015 Jul 09. - Publication Year :
- 2015
-
Abstract
- In Japan, cetuximab with concurrent bioradiotherapy (BRT) for squamous cell carcinoma of head and neck (SCCHN) was approved in December 2012. We herein report our initial experience of BRT, with special emphasis on acute toxicities of this combination therapy. Thirty-one non-metastatic SCCHN patients who underwent BRT using cetuximab between July 2013 and June 2014 were retrospectively evaluated. All patients received cetuximab with a loading dose of 400 mg/m(2) one week before the start of radiotherapy, followed by 250 mg/m(2) per week during radiotherapy. The median cycle of cetuximab was seven cycles and the median dose of radiotherapy was 70 Gy. Twenty-five patients (80.6%) accomplished planned radiotherapy and six cycles or more cetuximab administration. Six patients (19.4%) discontinued cetuximab. Grade 3 dermatitis, mucositis and infusion reaction occurred in 19.4%, 48.3% and 3.2%, respectively. One patient experienced Grade 3 gastrointestinal bleeding caused by diverticular hemorrhage during BRT. Grade 3 drug-induced pneumonitis occurred in two patients. The response rate was 74%, including 55% with a complete response. BRT using cetuximab for Japanese patients with SCCHN was feasible as an alternative for cisplatin-based concurrent chemoradiation, although longer follow-up is necessary to evaluate late toxicities.<br /> (© The Author 2015. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology.)
- Subjects :
- Aged
Aged, 80 and over
Dermatitis etiology
Follow-Up Studies
Humans
Japan
Middle Aged
Mucositis etiology
Radiation Injuries etiology
Radiotherapy Planning, Computer-Assisted
Retrospective Studies
Treatment Outcome
Antineoplastic Agents therapeutic use
Cetuximab therapeutic use
Head and Neck Neoplasms drug therapy
Head and Neck Neoplasms radiotherapy
Subjects
Details
- Language :
- English
- ISSN :
- 1349-9157
- Volume :
- 56
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of radiation research
- Publication Type :
- Academic Journal
- Accession number :
- 26160181
- Full Text :
- https://doi.org/10.1093/jrr/rrv038