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Vitamin B₂ Sensitizes Cancer Cells to Vitamin-C-Induced Cell Death via Modulation of Akt and Bad Phosphorylation.
- Source :
-
Journal of agricultural and food chemistry [J Agric Food Chem] 2015 Aug 05; Vol. 63 (30), pp. 6739-48. Date of Electronic Publication: 2015 Jul 24. - Publication Year :
- 2015
-
Abstract
- Vitamin C is an essential dietary nutrient that has a variety of biological functions. Recent studies have provided promising evidence for its additional health benefits, including anticancer activity. Vitamin B2, another essential dietary nutrient, often coexists with vitamin C in some fruits, vegetables, or dietary supplements. The objective of the present study is to determine whether the combination of vitamin C and B2 can achieve a synergistic anticancer activity. MDA-MB-231, MCF-7, and A549 cells were employed to evaluate the combinatory effects of vitamin C and B2. We found that the combination of vitamin C and B2 resulted in a synergistic cell death induction in all cell lines tested. Further mechanistic investigations revealed that vitamin B2 sensitized cancer cells to vitamin C through inhibition of Akt and Bad phosphorylation. Our findings identified vitamin B2 as a promising sensitizer for improving the efficacy of vitamin-C-based cancer chemoprevention and chemotherapy.
- Subjects :
- Breast Neoplasms drug therapy
Breast Neoplasms genetics
Breast Neoplasms physiopathology
Cell Line, Tumor
Drug Synergism
Female
Humans
Phosphorylation drug effects
Proto-Oncogene Proteins c-akt genetics
bcl-Associated Death Protein genetics
Apoptosis drug effects
Ascorbic Acid pharmacology
Breast Neoplasms metabolism
Proto-Oncogene Proteins c-akt metabolism
Riboflavin pharmacology
bcl-Associated Death Protein metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1520-5118
- Volume :
- 63
- Issue :
- 30
- Database :
- MEDLINE
- Journal :
- Journal of agricultural and food chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 26165392
- Full Text :
- https://doi.org/10.1021/acs.jafc.5b01909