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Association between self-report adherence measures and oestrogen suppression among breast cancer survivors on aromatase inhibitors.
- Source :
-
European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2015 Sep; Vol. 51 (14), pp. 1890-6. Date of Electronic Publication: 2015 Jul 10. - Publication Year :
- 2015
-
Abstract
- Purpose: Poor adherence to oral adjuvant hormonal therapy for breast cancer is a common problem, but little is known about the relationship between self-report adherence measures and hormonal suppression. We evaluated the relationship of three self-report measures of medication adherence and oestrogen among patients on aromatase inhibitors (AIs).<br />Materials and Methods: We recruited 235 women with breast cancer who were prescribed AI therapy. Participants self-reported AI adherence by completing the following: (1) a single item asking whether they took an AI in the last month, (2) a modified Morisky Medication Adherence Scale-8 (MMAS-8) and (3) the Visual Analog Scale (VAS). Serum estrone and estradiol were analysed using organic solvent extraction and Celite column partition chromatography, followed by radioimmunoassay.<br />Results: Ten percent of participants reported they had not taken an AI in the last month and among this group, median estrone (33.2 pg/ml [interquartile range (IQR)=22.3]) and estradiol levels (7.2 pg/mL [IQR=3.3]) were significantly higher than those in participants who reported AI use (median estrone=11.5 pg/mL [IQR=4.9]; median estradiol=3.4 pg/mL [IQR=2.1]; p<0.001). This relationship held when controlling for race and AI drug type.<br />Conclusions: A single-item monthly-recall adherence measure for AIs was associated with oestrogen serum levels. This suggests that patient-reported monthly adherence may be a useful measure to identify early non-adherence behaviour and guide interventions to improve patient adherence to hormonal treatment.<br /> (Copyright © 2015 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Breast Neoplasms blood
Breast Neoplasms enzymology
Breast Neoplasms pathology
Female
Humans
Middle Aged
Neoplasms, Hormone-Dependent enzymology
Neoplasms, Hormone-Dependent pathology
Pennsylvania
Predictive Value of Tests
Treatment Outcome
Antineoplastic Agents, Hormonal therapeutic use
Aromatase Inhibitors therapeutic use
Biomarkers, Tumor blood
Breast Neoplasms drug therapy
Drug Monitoring methods
Estradiol blood
Estrone blood
Medication Adherence
Neoplasms, Hormone-Dependent drug therapy
Self Report
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0852
- Volume :
- 51
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- European journal of cancer (Oxford, England : 1990)
- Publication Type :
- Academic Journal
- Accession number :
- 26169018
- Full Text :
- https://doi.org/10.1016/j.ejca.2015.06.113