BH3 profiling identifies heterogeneous dependency on Bcl-2 family members in multiple myeloma and predicts sensitivity to BH3 mimetics.

Authors :: Touzeau C
Ryan J
Guerriero J
Moreau P
Chonghaile TN
Le Gouill S
Richardson P
Anderson K
Amiot M
Letai A
Source :: Leukemia [Leukemia] 2016 Mar; Vol. 30 (3), pp. 761-4. Date of Electronic Publication: 2015 Jul 15.
Publication Year :: 2016

Subjects :: Aged
Aged, 80 and over
Aniline Compounds chemical synthesis
Aniline Compounds pharmacology
Antineoplastic Agents chemical synthesis
Biological Assay
Bridged Bicyclo Compounds, Heterocyclic chemical synthesis
Bridged Bicyclo Compounds, Heterocyclic pharmacology
Cell Line, Tumor
Cytochromes c metabolism
Female
Humans
Male
Middle Aged
Mitochondria drug effects
Mitochondria metabolism
Mitochondria pathology
Multiple Myeloma genetics
Multiple Myeloma metabolism
Multiple Myeloma pathology
Myeloid Cell Leukemia Sequence 1 Protein genetics
Myeloid Cell Leukemia Sequence 1 Protein metabolism
Organ Specificity
Peptides chemical synthesis
Plasma Cells drug effects
Plasma Cells metabolism
Plasma Cells pathology
Proto-Oncogene Proteins c-bcl-2 genetics
Proto-Oncogene Proteins c-bcl-2 metabolism
Recurrence
Sulfonamides chemical synthesis
Sulfonamides pharmacology
bcl-X Protein genetics
bcl-X Protein metabolism
Antineoplastic Agents pharmacology
Gene Expression Regulation, Neoplastic
Multiple Myeloma diagnosis
Myeloid Cell Leukemia Sequence 1 Protein antagonists & inhibitors
Peptides pharmacology
Proto-Oncogene Proteins c-bcl-2 antagonists & inhibitors
bcl-X Protein antagonists & inhibitors

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